recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. Immediate steps should be taken to limit its spread to the environment. Email us or use our contact form to request a list or copy of archived materials for the following meeting. Pentavalent antimony compounds have been used for the treatment of leishmaniasis. The in vivo genotoxicity of antimony trioxide was studied using single and repeat dose mouse bone marrow micronucleus tests, and the rat liver unscheduled DNA synthesis assay. Exposure to antimony trioxide may increase the risk of cancer. Chemical Status; Cancer: Currently listed. Results In typical case scenarios, the occupational cancer risk from antimony trioxide was estimated to be 0.025 (25 in 1000) for persons working with flame retardants in … Cancer; Listed as causing: Cancer. The Department of Health and Human Services (HHS) considers antimony trioxide to be reasonably anticipated to be a human carcinogen (causing cancer in people). ANTIMONY TRIOXIDE 256 Cancer There are inadequate data to assess the carcinogenicity of antimony trioxide from dermal or oral exposures. Arsenic trioxide is sometimes given in combination with another medicine called tretinoin. RESULTS:In typical case scenarios, the occupational cancer risk from antimony trioxide was estimated to be 0.025 (25 in 1000) for persons working … The .gov means it's official. Supplemental materials for events, meetings, and workshops prior to 2017 have been archived. Chemical compounds based on antimony are used as pigments – one of them, antimony trioxide is also used as a flame retardant in textiles and plastics. Antimony trioxide is primarily used as a flame retardant in rubber, plastics, pigments, adhesives, textiles, and paper. EPA has not classified antimony for carcinogenicity. Agency for Toxic Substances and Disease Registry. Before sharing sensitive information, make sure you're on a federal government site. Date of Listing: 10/01/1990. The US National Toxicology Program (NTP) recently recommended in its Report on Carcinogens Monograph for Antimony Trioxide that antimony trioxide be Federal government websites often end in .gov or .mil. The site is secure. This is only a partial list; employers are obliged to prevent the exposure of these workers to any agents that may cause adverse health effect for either mother or child. An expert panel, which met Jan. 24 via webcast, was unanimous in agreeing with National Toxicology Program (NTP) scientists that antimony trioxide should be classified as reasonably anticipated to be a human carcinogen in the Report on Carcinogens (RoC). This list contains substances to which pregnant workers and workers who have recently given birth or are breastfeeding may not be exposed. How can I protect myself and my family from antimony? Antimony trioxide is a respiratory carcinogen in female rats. Email: Contact CDC-INFO. Workers may be harmed from exposure to antimony and its compounds. Antimony sesquioxide; Antimonous oxide; Antimony oxide, Oxo-oxostibanyloxystibane; Diantimony trioxide Occurence(s)/Use(s) Component of flame retardant treatment for polymers; opacifying agent for glasses, ceramics, and enamels; specialty pigments; naturally occurring as valentinite and senarmontite Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. Diantimony Trioxide is listed as causing cancer (based on the IARC classification) in the California Proposition 65 or Safe Drinking Water and Toxic Enforcement Act of 1986. These clinics specialize in Groth DH, Stettler LE, Burg JR, Busey WM, Grant GC, Wong L. This study was initiated because of a suspected increase in incidence of lung cancer in antimony smelter workers in England. These archived materials frequently include presentations, background materials, and public comments. Antimony trioxide is classified as a carcinogen in the state of California. Carcinogenic effects of antimony trioxide and antimony ore concentrate in rats. The level of exposure depends upon the dose, duration, and work being done. Can I get a medical test to check for antimony? It has also been listed as a possible human carcinogen by the International Agency for Research on Cancer. The state of California lists antimony trioxide as a chemical known to cause cancer. Antimony trioxide was last classified by the International Agency for Research on Cancer (IARC) in 1989 as Group 2B, possibly carcinogenic to humans, based on inadequate evidence in humans and sufficient evidence in animals. Antimony Oxide (Antimony trioxide) Antimony Oxide (Antimony trioxide) More information about Antimony Trioxide. Fact Sheets; The International Agency for Research on Cancer has determined that antimony trioxide is possibly carcinogenic to humans and that antimony trisulfide is not classifiable. It is used to fireproof fabrics, paper and plastics, as a paint pigment and for many other uses. : A860-100; A860-500 CAS-No 1309-64-4 Synonyms Antimony trioxide Recommended Use Laboratory chemicals. For assistance, email us or use our contact form and identify the documents/pages for which access is required. A cancer assessment for antimony trioxide is not available on IRIS (U.S. EPA, 2008) or in the HEAST (U.S. EPA, 1997). Primarily used as a synergist for halogenated flame retardants in plastics, rubber, and textiles, all of which are used in a wide variety of consumer products. Reports on Peer Reviews for the Report on Carcinogens. Note: Javascript is disabled or is not supported by your browser. The primary hazard is the threat to the environment. Ahmed Mostafa, M.D., Ryan Surmaitis, D.O., Maricel Dela Cruz, D.O., Michael Greenberg, M.D., Muhammad Khalid, M.D. For more information go to www.P65Warnings.ca.gov The International Agency for Research on Cancer has concluded antimony trioxide is "possibly carcinogenic to humans" (IARC, 1989). Antimony is a silvery-white metal that is found in the earth's crust. level of evidence from cancer studies of antimony(III) trioxide in humans and experimental animals. Caroline Braibant - Human Health: Genotoxicity, Caroline Braibant - Human Health: Lung Toxicity and Carcinogenicity, Testing Status of Antimony Trioxide 10676-V, National Institute of Environmental Health Sciences, Federal Register notice requesting public comment on nominated substances (, Division of Medical Toxicology at Drexel University College of Medicine. We will assist you in accessing the content of these files. One compound — antimony trioxide — is even believed to be carcinogenic, and antimony poisoning has also been known to lead to Adams-Stokes syndrome. Evidence for lung neoplasms caused by antimony trioxide inhalation in e … However, there are companies in the United States that produce antimony … *Antimony Trioxidemay be a CARCINOGEN in humans since it has been shown to cause lung cancer in animals. They can potentially be exposed when using consumer products containing antimony trioxide or breathing contaminated air. Antimony trioxide was tested for carcinogenicity by inhalation exposure in male and female rats of one strain and in female rats of another strain, producing a significant increase in the incidence of lung tumours (scirrhous and squamous- cell carcinomas and bronchioloalveolar tumours) in … Identification Product Name Antimony(III) oxide Cat No. Basis for Listing AB-IARC. ATSDR can also tell you the location of occupational and environmental health clinics. An increased lung cancer risk cannot be excluded. Oxide of trivalent (+3) antimony and most commercially significant form of antimony. People are mainly exposed to antimony trioxide in the workplace. SAFETY DATA SHEET Creation Date 22-Dec-2009 Revision Date 18-Jan-2018 Revision Number 5 1. Antimony Oxide (Antimony trioxide) Antimony Oxide (Antimony trioxide) Listed as Causing Cancer. NIEHS has helpful information on accessibility. Antimony (Sb) is a silver-white brittle solid or a dark-gray, lustrous powder. WARNING: This product can expose you to antimony trioxide, which is known to the State of California to cause cancer. Antimony(III) oxide is the inorganic compound with the formula Sb 2 O 3.It is the most important commercial compound of antimony.It is found in nature as the minerals valentinite and senarmontite. Antimony carcinogenicity evidence involving workers is inadequate, based on confounding, small sample sizes, incomparability across studies, and inadequate reference populations. Basis for Listing: AB-IARC. In addition, the available mechanistic and other relevant data (such as disposition and toxicokinetics) are assessed, and the final listing recommendation is based on an integration of all the relevant information (as summarized in the table above). Like most polymeric oxides, Sb 2 O 3 dissolves in aqueous solutions with hydrolysis.A mixed arsenic-antimony oxide occurs in the nature as the very rare mineral stibioclaudetite. (di)antimony trioxide 1309-64-4 >98.0 lead monoxide 1317-36-8 <0.1% (di)arsenic trioxide 1327-53-3 <0.1% Section 4 - First Aid Measures Description of necessary measures, subdivided according to the different routes of exposure: General advice: If exposed or concerned: Get medical advice/attention. Typical and worst-case inhalation scenarios in multiple occupational settings were used in risk estimation. Antimony trioxide is a white crystalline solid. Rat oral LD 50 >34 g kg −1. It can be harmful to the eyes and skin. Note on Accessibility: Persons with disabilities or using assistive technology may find some documents are not fully accessible. All three studies were negative. It is insoluble in water. 888-232-6348 (TTY) Antimony trioxide is a compound used in the production of certain flame retardants and other industrial processes. What happens when I eat or breathe antimony? Proposition 65 requires businesses to determine if they must provide a warning about significant exposure to listed chemicals. Human studies are inconclusive regarding antimony exposure and cancer, while animal studies have reported lung tumors in rats exposed to antimony trioxide via inhalation. Little antimony is currently mined in the United States. 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